| Primary Identifier | MGI:1096550 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 13119 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable 16-hydroxypalmitate dehydrogenase activity; arachidonate binding activity; and monooxygenase activity. Predicted to be involved in fatty acid metabolic process; icosanoid biosynthetic process; and kidney development. Predicted to be located in apical plasma membrane; cytoplasm; and extracellular space. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in several structures, including adrenal gland; gut; hemolymphoid system gland; liver; and lung. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human CYP4A11 (cytochrome P450 family 4 subfamily A member 11) and CYP4A22 (cytochrome P450 family 4 subfamily A member 22). PHENOTYPE: Male mice homozygous for disruption of this gene display high blood pressure. Blood pressure is elevated in females as well to levels comparable to normotensive males. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
