| Primary Identifier | MGI:99523 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 18477 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables identical protein binding activity. Acts upstream of with a negative effect on canonical NF-kappaB signal transduction and regulation of non-canonical NF-kappaB signal transduction. Acts upstream of or within several processes, including natural killer cell mediated cytotoxicity; regulation of stress-activated MAPK cascade; and removal of superoxide radicals. Located in mitochondrion and myelin sheath. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in methylmalonic aciduria and homocystinuria type cblC. Orthologous to human PRDX1 (peroxiredoxin 1). PHENOTYPE: Mutant mice exhibit defects in antioxidant defense that manifest as hemolytic anemia and malignancies. The phenotype is more severe in homozygous mutant mice, which die prematurely. Homozygous KO reduces susceptibility to chemically induced skin cancer. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
