| Primary Identifier | MGI:95284 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 13615 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable endothelin B receptor binding activity and hormone activity. Involved in several processes, including axon extension; positive regulation of prostaglandin-endoperoxide synthase activity; and prostaglandin biosynthetic process. Acts upstream of or within several processes, including energy homeostasis; lung alveolus development; and positive regulation of smooth muscle contraction. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and skeleton. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human EDN2 (endothelin 2). PHENOTYPE: Mice homozygous for a knock-out allele exhibit growth retardation, hypothermia, hypoxemic hypoxia, hypercapnia, emphysema and premature death. Females exhibit impaired ovulation and a lack of corpora lutea formation. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
