| Primary Identifier | MGI:1926803 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 60613 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables voltage-gated potassium channel activity. Acts upstream of or within inner ear morphogenesis; potassium ion transport; and sensory perception of sound. Predicted to be located in plasma membrane. Predicted to be part of voltage-gated potassium channel complex. Is expressed in several structures, including gonad; hemolymphoid system gland; inner ear; retina; and vestibulo-cochlear ganglion. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 2A and sensorineural hearing loss. Orthologous to human KCNQ4 (potassium voltage-gated channel subfamily Q member 4). PHENOTYPE: Mice that are either homozygous for a knock-out allele or homozygous for a dominant negative knock-in allele exhibit a slowly progressive hearing loss due to chronic depolarization and subsequent degeneration of cochlear outer hair cells. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
