| Primary Identifier | MGI:2140364 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 100206 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables ADP-ribosylserine hydrolase activity and poly(ADP-ribose) glycohydrolase activity. Involved in negative regulation of necroptotic process and peptidyl-serine ADP-deribosylation. Acts upstream of or within cellular response to superoxide. Located in mitochondrion and nucleus. Human ortholog(s) of this gene implicated in stress-induced childhood-onset neurodegeneration with variable ataxia and seizures. Orthologous to human ADPRS (ADP-ribosylserine hydrolase). PHENOTYPE: Mice exhibit increased susceptibility to ischemic brain injury with increased mortality. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
