Primary Identifier | MGI:1922484 | Organism | mouse, laboratory |
Chromosome | 4 | NCBI Gene Number | 75234 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable ubiquitin binding activity; ubiquitin conjugating enzyme binding activity; and ubiquitin protein ligase activity. Acts upstream of or within natural killer cell mediated cytotoxicity. Located in cytolytic granule. Is expressed in cerebral cortex ventricular layer and cortical plate. Orthologous to human RNF19B (ring finger protein 19B). PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired NK cell cytolysis and an impaired ability to control introduced tumor cells. [provided by MGI curators] |