| Primary Identifier | MGI:1100836 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 16650 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables nuclear import signal receptor activity. Acts upstream of or within several processes, including entry of viral genome into host nucleus through nuclear pore complex via importin; positive regulation of macromolecule biosynthetic process; and protein import into nucleus. Predicted to be located in cytosol. Predicted to be part of NLS-dependent protein nuclear import complex. Predicted to be active in nucleoplasm. Is expressed in several structures, including gonad; heart; liver; lung; and spleen. Orthologous to human KPNA6 (karyopherin subunit alpha 6). PHENOTYPE: Female mice homozygous for a null mutation are infertile and show a block in zygotic genome activation. In male mice, homozygous deficiency results in multiple defects in both germ cells and Sertoli cells culminating in oligozoospermia. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
