| Primary Identifier | MGI:1913835 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 66585 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to be involved in RNA splicing and mRNA processing. Predicted to be located in cytosol and nuclear speck. Predicted to be part of U2-type catalytic step 2 spliceosome and U4/U6 x U5 tri-snRNP complex. Is expressed in cerebral cortex ventricular layer; liver; lung; metanephros; and submandibular gland primordium. Orthologous to human SNRNP40 (small nuclear ribonucleoprotein U5 subunit 40). PHENOTYPE: Mice homozygous for a knock-out allele show embryonic growth retardation, a small egg cylinder, disorganized extraembryonic tissue, failure to initiate gastrulation, and complete embryonic lethality by E9.5. Mice homozygous for a hypomorphic allelel exhibit reduced body weight, belly spotting, and immunodeficiency. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
