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Protein Coding Gene : Ptafr platelet-activating factor receptor
Primary Identifier  MGI:106066 Organism  mouse, laboratory
Chromosome  4 NCBI Gene Number  19204
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Enables lipopolysaccharide binding activity and lipopolysaccharide immune receptor activity. Acts upstream of or within inflammatory response; inositol trisphosphate biosynthetic process; and response to lipopolysaccharide. Predicted to be located in plasma membrane. Is expressed in blood; early conceptus; and liver. Orthologous to human PTAFR (platelet activating factor receptor).
PHENOTYPE: Inactivation of this locus affects the immune response. Homozygotes have a marked reduction in systemic anaphylactic symptoms but are otherwise healthy. Further studies showed delayed elimination of parasites, and resistance to pneumonococcal pneumonia infection. [provided by MGI curators]
  • synonyms:
  • MGD-MRK-33750,
  • PAFR,
  • PAF receptor,
  • platelet-activating factor receptor,
  • Ptafr
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Features --> Cross References

Genome

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4 Involved In Mutations

Trail: ProteinCodingGene

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0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

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Function

Mouse features --> Functions (GO terms)

Homology

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Interactions

9 Pathways

Trail: ProteinCodingGene

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Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

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