Primary Identifier | MGI:101908 | Organism | mouse, laboratory |
Chromosome | 4 | NCBI Gene Number | 14748 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable sphingosine-1-phosphate receptor activity. Involved in positive regulation of cold-induced thermogenesis. Acts upstream of or within regulation of meiotic nuclear division. Predicted to be active in cytoplasm and plasma membrane. Is expressed in central nervous system; eye; gonad; and salivary gland. Orthologous to human GPR3 (G protein-coupled receptor 3). PHENOTYPE: Mice homozygous for one allele display an increased thermal nociceptive threshold while females homozygous for another allele display age-related reproductive failure due to ovulation of a progressively increasing proportion of developmentally incompetent oocytes. [provided by MGI curators] |