Primary Identifier | MGI:1913509 | Organism | mouse, laboratory |
Chromosome | 4 | NCBI Gene Number | 66259 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables protein kinase inhibitor activity. Involved in long-term memory and positive regulation of inflammatory response. Located in postsynaptic density. Is expressed in several structures, including brain; genitourinary system; hemolymphoid system gland; liver; and stomach. Human ortholog(s) of this gene implicated in ovarian cancer; ovarian carcinoma; and prostate adenocarcinoma. Orthologous to human CAMK2N1 (calcium/calmodulin dependent protein kinase II inhibitor 1). PHENOTYPE: Homozygous null mice show exacerbated cardiac dysfunction, larger fibrosis area, higher incidence of premature ventricular contractions and higher susceptibility to ventricular tachycardia or ventricular fibrillation after myocardial infarction. [provided by MGI curators] |