| Primary Identifier | MGI:104642 | Organism | mouse, laboratory |
| Chromosome | 4 | Mgi Type | polymorphic pseudogene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable calcium ion binding activity; calcium-dependent phospholipase A2 activity; and phospholipid binding activity. Involved in defense response to Gram-positive bacterium; intestinal stem cell homeostasis; and prostaglandin biosynthetic process. Acts upstream of or within negative regulation of epithelial cell proliferation; regulation of endothelial cell proliferation; and somatic stem cell population maintenance. Located in mitochondrion. Is expressed in ileum; jejunum; and primary palate. Human ortholog(s) of this gene implicated in cholecystolithiasis; colorectal cancer; gastroesophageal reflux disease; and human immunodeficiency virus infectious disease. Orthologous to human PLA2G2A (phospholipase A2 group IIA). PHENOTYPE: Mutations in this gene influence susceptibility to intestinal adenomas. [provided by MGI curators] |
| specificity | From J:28799 The mouse strains C57BL/6, 129/Sv, and B10.RIII were found to be homozygous for the defective sPLA2 gene, whereas outbred CD-1:SW mice had variable genotype at this locus. BALB/c, C3H/HE, DBA/1, DBA/2, NZB/BIN, and MRL lpr/lpr mice had a normal sPLA2 genotype. |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
