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Protein Coding Gene : Ubr4 ubiquitin protein ligase E3 component n-recognin 4
Primary Identifier  MGI:1916366 Organism  mouse, laboratory
Chromosome  4 NCBI Gene Number  69116
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Enables calmodulin binding activity and ubiquitin protein ligase activity. Involved in endosome organization; positive regulation of autophagy; and ubiquitin-dependent protein catabolic process via the N-end rule pathway. Acts upstream of or within protein catabolic process and protein stabilization. Located in endosome. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human UBR4 (ubiquitin protein ligase E3 component n-recognin 4).
PHENOTYPE: Mice homozygous for a transgenic gene disruption exhibit neonatal lethality and decreased body size at birth. Mice homozygous for a null mutation display complete embryonic lethality during organogenesis with arrest of vitelline vascular remodeling. [provided by MGI curators]
  • synonyms:
  • gene model 1032, (NCBI),
  • ubiquitin protein ligase E3 component n-recognin 4,
  • 1810009A16Rik,
  • MGI:2685878,
  • Gm1032,
  • MGI:2444481,
  • expressed sequence N28143,
  • RIKEN cDNA 1810009A16 gene,
  • LOC381562,
  • N28143,
  • MGI:2140710,
  • zinc finger, UBR1 type 1,
  • Zubr1,
  • p600,
  • RIKEN cDNA A930005E13 gene,
  • Ubr4,
  • RIKEN cDNA D930005K06 gene,
  • mKIAA0462,
  • A930005E13Rik,
  • D930005K06Rik
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3 Involved In Mutations

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