Primary Identifier | MGI:1916832 | Organism | mouse, laboratory |
Chromosome | 4 | NCBI Gene Number | 69582 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable kinesin binding activity. Predicted to be involved in several processes, including autophagosome-lysosome fusion; late endosome to lysosome transport; and natural killer cell mediated cytotoxicity. Predicted to be located in autolysosome and lysosomal membrane. Predicted to be active in endosome membrane. Orthologous to human PLEKHM2 (pleckstrin homology and RUN domain containing M2). PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased leukocyte numbers and decreased susceptibility to Salmonella infection. [provided by MGI curators] |