Primary Identifier | MGI:1355322 | Organism | mouse, laboratory |
Chromosome | 4 | NCBI Gene Number | 50912 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable 3'-5'-RNA exonuclease activity; single-stranded RNA binding activity; and telomerase RNA binding activity. Acts upstream of or within positive regulation of mRNA cis splicing, via spliceosome. Predicted to be located in cytosol; euchromatin; and nucleoplasm. Predicted to be part of nuclear exosome (RNase complex) and small-subunit processome. Predicted to be active in nucleolus. Is expressed in several structures, including cerebral cortex; gonad; liver; metanephros; and muscle tissue. Orthologous to human EXOSC10 (exosome component 10). PHENOTYPE: Mice homozygous for a null allele exhibit reduced female fertility with defective GVBD and endomembrane components. [provided by MGI curators] |