Primary Identifier | MGI:2683486 | Organism | mouse, laboratory |
Chromosome | 4 | NCBI Gene Number | 68703 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables transcription coactivator activity and transcription corepressor activity. Acts upstream of or within chromatin remodeling and nervous system development. Located in nucleus. Part of histone deacetylase complex. Is expressed in several structures, including alimentary system; eye; genitourinary system; nervous system; and vibrissa. Orthologous to human RERE (arginine-glutamic acid dipeptide repeats). PHENOTYPE: Mice homozygous for disruptions in this gene display embryonic lethality with abnormalities in neural tube development, somite development, and in the embryonic heart. Mice homozygous for an ENU-induced allele exhibit narrow snouts, decreased body weight, renal agenesis and small eyes. [provided by MGI curators] |