Primary Identifier | MGI:2683486 | Organism | mouse, laboratory |
Chromosome | 4 | NCBI Gene Number | 68703 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables transcription coactivator activity and transcription corepressor activity. Acts upstream of or within chromatin remodeling; nervous system development; and positive regulation of DNA-templated transcription. Located in nucleus. Part of histone deacetylase complex. Is expressed in several structures, including alimentary system; eye; genitourinary system; nervous system; and vibrissa. Orthologous to human RERE (arginine-glutamic acid dipeptide repeats). PHENOTYPE: Mice homozygous for disruptions in this gene display embryonic lethality with abnormalities in neural tube development, somite development, and in the embryonic heart. Mice homozygous for an ENU-induced allele exhibit narrow snouts, decreased body weight, renal agenesis and small eyes. [provided by MGI curators] |