| Primary Identifier | MGI:97602 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 18762 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables protein serine/threonine kinase activity. Involved in positive regulation of T-helper 2 cell differentiation and positive regulation of cytokine production. Acts upstream of or within several processes, including neuron projection extension; protein localization to plasma membrane; and protein phosphorylation. Located in several cellular components, including axon hillock; myelin sheath abaxonal region; and nucleus. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and sensory organ. Orthologous to human PRKCZ (protein kinase C zeta). PHENOTYPE: Young, not mature, homozygous null mice have reduced B cell numbers and abnormal secondary lymph organ structure. Young mice have fewer Peyer's patches, poor delineation of B & T cell zones, and fewer follicles of small size. Spleens have less prominent B cell follicles and abnormal marginal zones. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
