| Primary Identifier | MGI:1916241 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 68991 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable RNA polymerase II CTD heptapeptide repeat phosphatase activity. Predicted to be involved in co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway and termination of RNA polymerase II transcription. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of mRNA cleavage and polyadenylation specificity factor complex. Is expressed in facial ganglion; trigeminal ganglion; and vestibulo-cochlear ganglion. Used to study liver disease. Orthologous to human SSU72 (SSU72 homolog, RNA polymerase II CTD phosphatase). PHENOTYPE: Mice with liver-specific deletion show impaired regulation of hepatocyte chromosome polyploidization, impaired liver damage response with fibrosis, steatosis and steatohepatitis, and deregulation of hepatocyte cell cycle progression. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
