Primary Identifier | MGI:1922011 | Organism | mouse, laboratory |
Chromosome | 4 | NCBI Gene Number | 74761 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Involved in establishment of glial blood-brain barrier. Located in cell surface. Is expressed in brain ventricle and choroid plexus; cerebral cortex ventricular layer; heart valve; meninges; and skeleton. Orthologous to human MXRA8 (matrix remodeling associated 8). PHENOTYPE: Phenotypic analysis of mice homozygous for a gene trap allele indicates this mutation has no notable phenotype in any parameter tested in a high-throughput screen. Mice homozygous for two alleles with intragenic deletions in the Ig-like domain 2 show decreased infection of musculoskeletal tissues with various alphaviruses. [provided by MGI curators] |