Primary Identifier | MGI:2676875 | Organism | mouse, laboratory |
Chromosome | 4 | NCBI Gene Number | 387243 |
Mgi Type | miRNA gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; miRNA-mediated post-transcriptional gene silencing; and neuron differentiation. Is expressed in several structures, including epithelium; gut; palatal shelf; sensory organ; and skin. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human MIR200B (microRNA 200b). PHENOTYPE: Mice homozygous for knock-out alleles for Mir429 and Mir200b exhibit reduced female ferility due to reduced ovulation and impaired luteinizing hormone production. [provided by MGI curators] |