| Primary Identifier | MGI:97570 | Organism | mouse, laboratory |
| Chromosome | 5 | NCBI Gene Number | 18671 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0) Enables ATP hydrolysis activity; ATPase-coupled intramembrane lipid carrier activity; and transmembrane transporter activity. Involved in several processes, including lipid translocation; terpenoid transport; and xenobiotic transport across blood-brain barrier. Acts upstream of or within several processes, including aldosterone secretion; heart development; and neural tissue regeneration. Located in intercellular canaliculus. Is active in apical plasma membrane. Is expressed in several structures, including central nervous system; eye; genitourinary system; gut; and integumental system. Used to study inflammatory bowel disease 13. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); drug dependence (multiple); human immunodeficiency virus infectious disease (multiple); inflammatory bowel disease (multiple); and leukemia (multiple). Orthologous to human ABCB1 (ATP binding cassette subfamily B member 1). PHENOTYPE: Mutations in this gene result in increased sensitivity to various drugs, including avermectins and vinblastine. Mice with a null allele develop spontanous colitis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
