| Primary Identifier | MGI:107899 | Organism | mouse, laboratory |
| Chromosome | 5 | NCBI Gene Number | 12491 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables lipoprotein particle binding activity; lipoteichoic acid immune receptor activity; and low-density lipoprotein particle receptor activity. Involved in several processes, including negative regulation of macromolecule biosynthetic process; positive regulation of intracellular signal transduction; and positive regulation of metabolic process. Acts upstream of or within several processes, including phagocytosis; positive regulation of cytokine production; and response to bacterium. Located in several cellular components, including brush border membrane; external side of plasma membrane; and membrane raft. Is expressed in several structures, including axial skeleton; bone; connective tissue; hindlimb; and telencephalon. Used to study platelet-type bleeding disorder 10. Human ortholog(s) of this gene implicated in several diseases, including blood platelet disease (multiple); hemolytic-uremic syndrome; osteoarthritis; pulmonary tuberculosis; and type 2 diabetes mellitus. Orthologous to human CD36 (CD36 molecule (CD36 blood group)). PHENOTYPE: Homozygous mutant mice exhibit an immunodeficiency phenotype, are susceptible to S. aureus infection and develop ocular pterygium. Mice homozygous for disruptions in this gene display abnormal lipid homeostasis which affects energy utilization in the heart. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
