| Primary Identifier | MGI:2159339 | Organism | mouse, laboratory |
| Chromosome | 5 | NCBI Gene Number | 171209 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables enterobactin transmembrane transporter activity and monoatomic cation channel activity. Acts upstream of or within several processes, including detection of stimulus involved in sensory perception of pain; response to acidic pH; and response to heat. Located in plasma membrane. Is expressed in cranial ganglion; dorsal root ganglion; and pectoral girdle and thoracic body wall muscle. Orthologous to human ASIC3 (acid sensing ion channel subunit 3). PHENOTYPE: Homozygotes for targeted null mutations exhibit reduced latency to onset of pain responses, increased sensitivity to light touch, but decreased sensitivity to noxious pinch and responses of acid- and noxious heat-sensitive nociceptors. [provided by MGI curators] |