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Protein Coding Gene : Asic3 acid-sensing ion channel 3

Primary Identifier  MGI:2159339 Organism  mouse, laboratory
Chromosome  5 NCBI Gene Number  171209
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Enables enterobactin transmembrane transporter activity and monoatomic cation channel activity. Acts upstream of or within several processes, including detection of stimulus involved in sensory perception of pain; response to acidic pH; and response to heat. Located in plasma membrane. Is expressed in cranial ganglion; dorsal root ganglion; and pectoral girdle and thoracic body wall muscle. Orthologous to human ASIC3 (acid sensing ion channel subunit 3).
PHENOTYPE: Homozygotes for targeted null mutations exhibit reduced latency to onset of pain responses, increased sensitivity to light touch, but decreased sensitivity to noxious pinch and responses of acid- and noxious heat-sensitive nociceptors. [provided by MGI curators]
  • synonyms:
  • Accn3,
  • DRASIC,
  • expressed sequence AW742291,
  • acid-sensing ion channel 3,
  • AW742291,
  • Asic3,
  • MGI:2141243,
  • amiloride-sensitive cation channel 3

Features --> Cross References

Genome

Sequence Feature Displayer

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0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

4 Involved In Mutations

0 Strain

0 Transcripts

2 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

3 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

Other

0 Driver For