| Primary Identifier | MGI:96559 | Organism | mouse, laboratory |
| Chromosome | 5 | NCBI Gene Number | 16193 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables cytokine activity and interleukin-6 receptor binding activity. Involved in several processes, including liver development; lymphocyte activation involved in immune response; and positive regulation of macromolecule biosynthetic process. Acts upstream of or within with a positive effect on gene expression. Acts upstream of or within several processes, including positive regulation of cell population proliferation; regulation of gene expression; and salivary gland morphogenesis. Located in external side of plasma membrane. Part of interleukin-6 receptor complex. Is active in extracellular space. Is expressed in several structures, including adrenal gland; early conceptus; genitourinary system; hemolymphoid system; and intestine. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); gastrointestinal system cancer (multiple); glucose metabolism disease (multiple); and periodontal disease (multiple). Orthologous to human IL6 (interleukin 6). PHENOTYPE: Homozygous null mutants show impaired immune response to pathogens, decreased T cell numbers and resistance to plasma cell neoplasia. They are defective in wound healing and liver regeneration and show increased emotionality and high bone turnover rate. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
