| Primary Identifier | MGI:88375 | Organism | mouse, laboratory |
| Chromosome | 5 | NCBI Gene Number | 12615 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable DNA binding activity and protein heterodimerization activity. Predicted to be a structural constituent of chromatin. Acts upstream of or within protein localization to chromosome, centromeric region. Located in CENP-A containing chromatin; condensed chromosome, centromeric region; and pericentric heterochromatin. Is expressed in 2-cell stage embryo; cerebral cortex ventricular layer; epiblast; germ cell of gonad; and nephrogenic zone. Human ortholog(s) of this gene implicated in autoimmune disease. Orthologous to human CENPA (centromere protein A). PHENOTYPE: Homozygous mutation of this gene results in embryonic lethality between E3.5 and E10.5. Embryogenesis is impaired due to chromosomal missegregation, aneuploidy, and apoptosis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
