Primary Identifier | MGI:2675617 | Organism | mouse, laboratory |
Chromosome | 5 | NCBI Gene Number | 272158 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable DNA-directed DNA polymerase activity and cyclin binding activity. Predicted to be involved in double-strand break repair via homologous recombination; interstrand cross-link repair; and translesion synthesis. Predicted to act upstream of or within DNA-templated DNA replication. Predicted to be located in nucleoplasm. Is expressed in stomach and testis. Orthologous to human POLN (DNA polymerase nu). PHENOTYPE: Mice homozygous for a knock-out allele exhibit reduced meiotic double-strand breaks at a meiotic recombination hot spot harboring insertion/deletion polymorphisms, but are otherwise normal. [provided by MGI curators] |