| Primary Identifier | MGI:96829 | Organism | mouse, laboratory |
| Chromosome | 5 | NCBI Gene Number | 16976 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables low-density lipoprotein particle receptor binding activity. Predicted to be involved in several processes, including amyloid-beta clearance by transcytosis; negative regulation of amyloid-beta clearance; and negative regulation of very-low-density lipoprotein particle clearance. Predicted to be located in Golgi apparatus; endoplasmic reticulum; and vesicle. Predicted to be active in several cellular components, including cis-Golgi network; endoplasmic reticulum-Golgi intermediate compartment; and rough endoplasmic reticulum lumen. Is expressed in several structures, including central nervous system; egg cylinder; foregut; genitourinary system; and lung. Human ortholog(s) of this gene implicated in Alzheimer's disease; dementia; myocardial infarction; and myopia. Orthologous to human LRPAP1 (LDL receptor related protein associated protein 1). PHENOTYPE: Mice homozygous for disruptions in this gene display an essentially normal phenotype. However, subtle abnormalities are seen in behavior, brain function and thyroid function. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
