| Primary Identifier | MGI:1932289 | Organism | mouse, laboratory |
| Chromosome | 5 | NCBI Gene Number | 81840 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Involved in intracellular protein transport and long-term synaptic depression. Located in endosome membrane; plasma membrane; and postsynaptic density. Is expressed in several structures, including brain; future spinal cord; musculature; sensory organ; and spinal cord. Orthologous to human SORCS2 (sortilin related VPS10 domain containing receptor 2). PHENOTYPE: Homozygous inactivation of this gene leads to reduced dopamine levels and dopamine metabolism, dopaminergic hyperinnervation of the frontal cortex, hyperactivity, abnormal behavioral response to amphetamine, and decreased induction of Schwann cell apoptosis following sciatic nerve injury. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
