Primary Identifier | MGI:107470 | Organism | mouse, laboratory |
Chromosome | 5 | NCBI Gene Number | 17089 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable several functions, including DNA-binding transcription factor binding activity; identical protein binding activity; and transcription regulator inhibitor activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of phagocytosis. Located in nucleolus and photoreceptor outer segment. Is expressed in several structures, including gonad; hemolymphoid system; jaw; liver; and metanephros. Orthologous to human LYAR (Ly1 antibody reactive). PHENOTYPE: Mice homozygous for a knock-out allele exhibit reduced proliferation of mouse embryonic fibroblasts and results in female prenatal lethality when presnt with a Trp53 null allele. [provided by MGI curators] |