| Primary Identifier | MGI:1351468 | Organism | mouse, laboratory |
| Chromosome | 5 | NCBI Gene Number | 27278 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Involved in several processes, including mast cell degranulation; negative regulation of natural killer cell activation; and positive regulation of natural killer cell cytokine production. Acts upstream of or within cell surface receptor protein tyrosine kinase signaling pathway. Located in mast cell granule. Part of protein-containing complex. Orthologous to human CLNK (cytokine dependent hematopoietic cell linker). PHENOTYPE: Mice homozygous for a reporter allele display altered natural killer (NK) T cell physiology and enhanced NK cell cytolysis. Mice homozygous for knock-out allele display abnormal mast cell physiology as well as enhanced NK cell cytolysis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
