Primary Identifier | MGI:1918168 | Organism | mouse, laboratory |
Chromosome | 5 | NCBI Gene Number | 70918 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable RNA binding activity and methyltransferase activity. Acts upstream of or within flagellated sperm motility and sperm mitochondrion organization. Is expressed in several structures, including branchial arch; central nervous system; extraembryonic component; neural ectoderm; and sensory organ. Orthologous to human NSUN7 (NOP2/Sun RNA methyltransferase family member 7). PHENOTYPE: Males homozygous for an ENU-induced mutation are either infertile or subfertile. Mutant sperm exhibit poor progressive motility linked to rigidity of the flagellar midpiece and abnormal electron density patterns in the mitochondrial sheath. [provided by MGI curators] |