| Primary Identifier | MGI:1924819 | Organism | mouse, laboratory |
| Chromosome | 5 | NCBI Gene Number | 77569 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable myosin II head/neck binding activity. Predicted to be involved in several processes, including cytoplasmic actin-based contraction involved in cell motility; positive regulation of stress fiber assembly; and regulation of focal adhesion assembly. Predicted to be located in cytoplasm. Predicted to be part of myosin II complex. Predicted to be active in stress fiber. Is expressed in several structures, including cardiovascular system; gonad; gut; hemolymphoid system gland; and nervous system. Orthologous to human LIMCH1 (LIM and calponin homology domains 1). PHENOTYPE: Mice homozygous for a deletion of the six exons encoding the muscle-specific isoform, exclusively express the fetal predominant isoform in adult skeletal muscle and show decreased grip strength, muscle weakness, deficits in skeletal muscle force generation, and defects in calcium-handling during myofiber stimulation. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
