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Protein Coding Gene : Usp46 ubiquitin specific peptidase 46
Primary Identifier  MGI:1916977 Organism  mouse, laboratory
Chromosome  5 NCBI Gene Number  69727
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Enables deubiquitinase activity. Involved in regulation of GABAergic synaptic transmission. Acts upstream of or within several processes, including adult feeding behavior; behavioral fear response; and behavioral response to ethanol. Predicted to be located in cytoplasm. Predicted to be active in cytosol; glutamatergic synapse; and nucleus. Is expressed in cerebral cortex intermediate zone; cortical plate; and pancreas epithelium. Orthologous to human USP46 (ubiquitin specific peptidase 46).
PHENOTYPE: Mice homozygous for a gene trap allele exhibit reduced depression-related behaviors. [provided by MGI curators]
  • synonyms:
  • expressed sequence AI451644,
  • MGI:2140899,
  • MGI:1916152,
  • 1190009E20Rik,
  • Usp46,
  • RIKEN cDNA 1190009E20 gene,
  • 2410018I08Rik,
  • RIKEN cDNA 2410018I08 gene,
  • ubiquitin specific peptidase 46,
  • AI451644
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6 Involved In Mutations

Trail: ProteinCodingGene

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Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

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