| Primary Identifier | MGI:3029632 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 327987 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0) Predicted to enable nuclear thyroid hormone receptor binding activity and transcription coactivator activity. Involved in cholesterol homeostasis; negative regulation of transcription by RNA polymerase II; and triglyceride homeostasis. Part of mediator complex. Is expressed in several structures, including central nervous system; early embryo; gut; hemolymphoid system gland; and reproductive system. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 61. Orthologous to human MED13 (mediator complex subunit 13). PHENOTYPE: Mice homozygous for a conditional allele exhibited in the heart exhibit increased susceptibility to obesity and worsened glucose intolerance when fed a high fat diet. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
