Primary Identifier | MGI:1860130 | Organism | mouse, laboratory |
Chromosome | 5 | NCBI Gene Number | 104443 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable G protein-coupled receptor activity and peptide binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway and cellular response to hormone stimulus. Predicted to act upstream of or within signal transduction. Predicted to be located in actin cytoskeleton. Predicted to be active in plasma membrane. Is expressed in brain; dorsal root ganglion; and trigeminal ganglion. Orthologous to human NPFFR2 (neuropeptide FF receptor 2). PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased litter size and sex-specific increased susceptibility to diet-induced obesity and adipose accumulation, impaired diet-induced thermogenesis, and altered bone thickness. [provided by MGI curators] |