Primary Identifier | MGI:1932101 | Organism | mouse, laboratory |
Chromosome | 5 | NCBI Gene Number | 81702 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable chromatin binding activity. Acts upstream of or within blood vessel maturation and negative regulation of smooth muscle cell differentiation. Located in male germ cell nucleus. Is expressed in several structures, including alimentary system; gonad; liver; nervous system; and septum transversum. Orthologous to human ANKRD17 (ankyrin repeat domain 17). PHENOTYPE: Mice homozygous for a null mutation display embryonic lethality during organogenesis with hemorrhages, impaired vascular smooth muscle cell development, impaired vascular integrity, and growth retardation. [provided by MGI curators] |