Primary Identifier | MGI:1919170 | Organism | mouse, laboratory |
Chromosome | 5 | NCBI Gene Number | 71920 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables epidermal growth factor receptor binding activity; growth factor activity; and transmembrane receptor protein tyrosine kinase activator activity. Involved in epidermal growth factor receptor signaling pathway; positive regulation of epithelial cell proliferation; and positive regulation of mitotic nuclear division. Acts upstream of or within MAPK cascade. Is active in extracellular space. Is expressed in several structures, including alimentary system; arterial system; dorsal root ganglion; hair follicle; and male reproductive gland or organ. Orthologous to human EPGN (epithelial mitogen). PHENOTYPE: Mice homozygous for a knock-out allele exhibit moderate increase in absolute pancreas and spleen weight but normal epidermis and pilosebaceous unit development. [provided by MGI curators] |