| Primary Identifier | MGI:2679683 | Organism | mouse, laboratory |
| Chromosome | 5 | NCBI Gene Number | 231474 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables ubiquitin-like ligase-substrate adaptor activity. Involved in negative regulation of peroxisome proliferator activated receptor signaling pathway and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Acts upstream of or within negative regulation of MAP kinase activity. Predicted to be located in Golgi membrane. Predicted to be active in Golgi apparatus. Is expressed in cerebral cortex intermediate zone and cortical plate. Orthologous to human PAQR3 (progestin and adipoQ receptor family member 3). PHENOTYPE: Targeted deletion of this gene causes faster chemical carcinogen-induced skin cell proliferation, higher epidermal thickness, increased number and size of skin papillomas, shorter tumor latency and delayed tumor regression. Heterozygotes develop tumors earlier and more frequently than control mice. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
