Primary Identifier | MGI:101947 | Organism | mouse, laboratory |
Chromosome | 5 | NCBI Gene Number | 11991 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable chromatin binding activity; histone deacetylase binding activity; and nucleic acid binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within regulation of mRNA stability. Is active in synapse. Is expressed in several structures, including branchial arch; central nervous system; genitourinary system; hemolymphoid system gland; and sensory organ. Orthologous to human HNRNPD (heterogeneous nuclear ribonucleoprotein D). PHENOTYPE: Homozygous mutation of this gene results in fetal growth retardation and decreased body weight. Mice show increased susceptibility to bacterial infection and endotoxin shock. [provided by MGI curators] |