| Primary Identifier | MGI:1343124 | Organism | mouse, laboratory |
| Chromosome | 5 | NCBI Gene Number | 15442 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables heparanase activity. Involved in several processes, including heparan sulfate proteoglycan catabolic process; positive regulation of osteoblast proliferation; and positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Located in membrane raft and nucleus. Is active in extracellular space. Is expressed in oral region gland; sensory organ; skeleton; submandibular gland primordium; and urinary system. Orthologous to human HPSE (heparanase). PHENOTYPE: Mice homozygous for a null allele exhibit precocious mammry gland development, increased angiogenesis and increased neovascularization. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
