Primary Identifier | MGI:2151221 | Organism | mouse, laboratory |
Chromosome | 5 | NCBI Gene Number | 117109 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables ribonuclease P activity. Acts upstream of or within tRNA processing. Part of nucleolar ribonuclease P complex. Is expressed in Meckel's cartilage and skeleton. Orthologous to human POP5 (POP5 homolog, ribonuclease P/MRP subunit). PHENOTYPE: Mice homozygous for a knock-out allele show failure of morula compaction and embryonic lethality before implantation. In vitro outgrowth assays show that embryos fail to hatch from the zona pellucida and die after 3 days in culture, never forming blastocysts. [provided by MGI curators] |