| Primary Identifier | MGI:2180781 | Organism | mouse, laboratory |
| Chromosome | 5 | NCBI Gene Number | 170756 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential and protein homodimerization activity. Involved in calcium export from the mitochondrion; intracellular calcium ion homeostasis; and regulation of lymphocyte chemotaxis. Acts upstream of or within mitochondrial calcium ion transmembrane transport and sodium ion transmembrane transport. Located in mitochondrion and plasma membrane. Is expressed in forelimb bud. Orthologous to human SLC8B1 (solute carrier family 8 member B1). PHENOTYPE: Mice homozygous for an inducible conditional allele exhibit premature death with cardiac failure, fibrosis, hypertrophy, and swollen mitochondria in tamoxifen-treated mice. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
