Primary Identifier | MGI:1923551 | Organism | mouse, laboratory |
Chromosome | 5 | NCBI Gene Number | 231712 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable zinc ion binding activity. Involved in negative regulation of innate immune response. Predicted to be active in mitochondrion. Is expressed in central nervous system and neural retina. Orthologous to human TRAFD1 (TRAF-type zinc finger domain containing 1). PHENOTYPE: Mice homozygous for a null allele exhibit increased susceptibility to endotoxin shock and decreased susceptibility to viral infection. [provided by MGI curators] |