Primary Identifier | MGI:1914647 | Organism | mouse, laboratory |
Chromosome | 5 | NCBI Gene Number | 67397 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable protein homodimerization activity and protein-folding chaperone binding activity. Involved in regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway. Located in cell surface. Is expressed in Meckel's cartilage and pancreas epithelium. Orthologous to human ERP29 (endoplasmic reticulum protein 29). PHENOTYPE: Mice homozygous for a null allele exhibit decreased thyrocyte and dermal fibroblast apoptosis sensitivities to induced ER stress and slightly reduced litter sizes. [provided by MGI curators] |