Primary Identifier | MGI:2443138 | Organism | mouse, laboratory |
Chromosome | 5 | NCBI Gene Number | 269702 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Involved in negative regulation of cilium assembly. Located in centrosome. Is expressed in embryo. Human ortholog(s) of this gene implicated in multiple sclerosis. Orthologous to human MPHOSPH9 (M-phase phosphoprotein 9). PHENOTYPE: Mice homozygous for a knock-out allele exhibit a twisted body axis at midgestation, decreased weight and an increased percentage of ciliated cells in the proximal and distal tubules. [provided by MGI curators] |