| Primary Identifier | MGI:1929269 | Organism | mouse, laboratory |
| Chromosome | 5 | NCBI Gene Number | 56334 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables frizzled binding activity and smoothened binding activity. Involved in embryonic morphogenesis; labyrinthine layer blood vessel development; and maternal placenta development. Acts upstream of or within several processes, including chordate embryonic development; regulation of gene expression; and regulation of signal transduction. Located in Golgi apparatus; endoplasmic reticulum membrane; and endoplasmic reticulum-Golgi intermediate compartment. Is expressed in several structures, including cardiovascular system; early conceptus; embryo ectoderm; placenta; and trunk mesenchyme. Orthologous to human TMED2 (transmembrane p24 trafficking protein 2). PHENOTYPE: Mice homozygous for an ENU-induced allele exhibit embryonic lethality, embryonic growth retardation, caudal body truncation, and abnormal heart development. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
