| Primary Identifier | MGI:2140796 | Organism | mouse, laboratory |
| Chromosome | 5 | NCBI Gene Number | 100561 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables L-histidine transmembrane transporter activity and peptide:proton symporter activity. Involved in several processes, including L-histidine transmembrane export from vacuole; positive regulation of pattern recognition receptor signaling pathway; and regulation of isotype switching to IgG isotypes. Located in early endosome membrane and lysosomal membrane. Is expressed in embryo. Orthologous to human SLC15A4 (solute carrier family 15 member 4). PHENOTYPE: Mice homozygous for an ENU-induced mutation display abrogation of both Toll-like receptor (TLR)-induced type I IFN and proinflammatory cytokine production by plasmacytoid dendritic cells. Mice homozygous for a knock-out allele show impaired TLR9-and NOD1-mediated cytokine production and decreased susceptibility to DSS-induced colitis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
