Primary Identifier | MGI:108059 | Organism | mouse, laboratory |
Chromosome | 5 | NCBI Gene Number | 13852 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables calcium-dependent protein binding activity. Involved in acrosome reaction. Acts upstream of or within cell differentiation. Located in several cellular components, including cell surface; cell-cell junction; and membrane raft. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; nervous system; and respiratory system. Orthologous to human STX2 (syntaxin 2). PHENOTYPE: Mice homozygous for a null allele display male infertility associated with abnormal testicular development and impaired spermatogenesis, increased intestinal growth due to enhanced crypt cell proliferation and crypt fission, and decreased susceptibility to induced colitis. [provided by MGI curators] |