| Primary Identifier | MGI:1313314 | Organism | mouse, laboratory |
| Chromosome | 5 | NCBI Gene Number | 12740 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable identical protein binding activity. Involved in paracellular transport and renal absorption. Located in apicolateral plasma membrane and bicellular tight junction. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system gland; salivary gland primordium; and sensory organ. Human ortholog(s) of this gene implicated in ovarian cancer and pancreatic cancer. Orthologous to human CLDN4 (claudin 4). PHENOTYPE: Mice homozygous for a knock-out allele exhibit hydropherosis due to kidney pelvis and ureteral urothelium proliferation that leads to impaired calcium and chloride ion reabsorbtion and premature death. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
